Low circulating dihomo-gamma-linolenic acid is associated with diabetic retinopathy: a cross sectional study of KAMOGAWA-DM cohort study

Diabetic retinopathy (DR), one of the major complications diabetes, can cause blindness and reduce quality life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed investigate association circulating n-3 n-6 polyunsaturated fatty acids (PUFAs) In this cross-sectional study, 190 Japanese patients type 2 diabetes were classified as no diabetic (NDR), simple (SDR), or proliferative (PDR) including pre-proliferative retinopathy. Circulating (FAs) measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed between levels FAs presence The average age, body mass index duration 62.7 ± 12.1 years, 25.0 4.5 kg/m2, 9.8 8.7 respectively. Twenty-seven diagnosed dihomo-gamma-linolenic (DGLA) in NDR (n = 163), SDR 13) PDR 14) groups 28.3 11.0 ?g/mL, 24.4 9.7 21.8 6.2 respectively (p 0.032). logarithm DGLA DR after adjusting for covariates (OR 1-unit increment: 0.79, 95% CI: 0.62–1.00, p 0.049). negatively